Offres d'emplois et de Post-Doc
|Post-Doc position available in Orsay|
University of Paris — France
A 2 years post-doctoral position is available immediately at the Laboratoire de Physique des Solides (University Paris XI) to study DNA-DNA interactions and DNA conformation in confined and condensed state. We are particularly interested in the structure of DNA inside the bacteriophage capsid in vivo and in vitro. The project includes bacteriophage and bacterial receptor protein purification, and imaging and analysis by cryo-electron microscopy, cryo-electron microscopy of vitreous sections (CEMOVIS) and cryo-electron tomography. The candidate will join a multidisciplinary team including physicists and biologists specialized in DNA, with expertise in cryoTEM and Xray diffraction.
The successful candidate should have a PhD or equivalent in structural biology or biophysics and previous experience in cryoelectron microscopy and/or virus and protein purification.
Applications including a CV, statement of interests and the names of three references should be send to firstname.lastname@example.org.
|Junior team leader position at the IBS|
Grenoble — France
The Institut de Biologie Structurale of Grenoble is currently seeking a junior group leader to create a new research team in the field of structural biology.
The IBS performs interdisciplinary research in integrated structural biology along 5 main axes: Immunity and Host-Pathogen Interactions, Fundamental Intracellular Processes, Limits of Life, Membrane Proteins and New Methodologies for Integrated Structural Biology. Research activities benefit from key technologies installed at the IBS: High-field NMR (5 spectrometers including a 950 MHz available in 2014), electron microscopy (3 microscopes including a Polara 300 kV), privileged access to synchrotron beam-lines and neutron instruments, confocal microscopy, and an ensemble of instrumentations to produce and characterize biological samples at a molecular level. The Partnership for Structural Biology (PSB) linking IBS to EMBL (Grenoble outstation), ESRF (European synchrotron radiation facility) and ILL (European neutron reactor), forms one of the largest European Centers in Structural Biology.
Applicants are expected to propose an independent research project related to the 5 main axes. Proposals at the interface with physics or with chemistry, bringing new approaches to the IBS are particularly encouraged. Candidates with excellent track record are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to email@example.com before the 30th of May 2013. Successful candidates are expected to apply to young investigator programs (ATIP-Avenir , ERC, and others) for funding.
|PhD fellowship in fluorescence microscopy and cell biophysics|
One PhD position is available in the team "Spatio-temporal regulation of transcription in eukaryotes", located at the Institute of Genetics and Development of Rennes (http://igdr.univrennes1. fr/), which hosts 200 people organized in 20 teams working on genetics, developmental biology, cell biology and biophysics. The PhD project will be supervised by Dr. Sébastien Huet, a young biophysicist who joined the team in November 2010. It will involve a collaboration with the group headed by Dr. Gyula Timinszky at the LMU university in Munich (Germany). The position is funded for 3 years (usual PhD duration in France), with a gross salary of 1650€ per month.
This PhD project is at the interface between biology, physics and microscopy and its objective is to gain insight in the understanding of the chromatin reorganization process in response to DNA damage. The chromatin fiber contained in the nucleus of eukaryotic interphase cells is characterized by a complex multi-scale architecture, which plays an important role in several key cellular functions such as transcription, DNA replication or DNA repair. More specifically, the poly-ADP-ribose (PAR) signaling pathway controls some of the chromatin restructuring events associated with the cellular early response to DNA damage. In this project, we propose to study the dynamics of PARylation and the way it regulates chromatin structure upon DNA damage. To reach this goal, the PhD student will develop advanced live cell fluorescence imaging methodologies to characterize quantitatively and with exquisite spatio-temporal resolution, the chromatin remodeling events occurring at the DNA damage sites. Ultimately, the project will identify the dynamic regulatory connections between ADPribosylation networks and chromatin remodeling at DNA lesions.
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|Poste de Professeur du Muséum national d’Histoire naturelle, Paris
Métabolomique environnementale : rôle des métabolites dans les mécanismes adaptatifs des micro-organismes
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|Postdoctoral position, immediately available with initial funding for 2 years.
Interdisciplinary Research Institute, Lille, France
The project is devoted to structure resolution by NMR spectroscopy of protein(s) involved in transcriptional regulation.
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Page mise à jour le 30/04/2013